Influenza A virus reassigns its own polymerase toward genome synthesis using a small RNA copied from its genome termini
lab-led
Discoveries
Each entry states one thing that is now known, the evidence that establishes it, and the boundary beyond which it is not established. Statements that only become visible when several publications are read together are marked as synthesis, since no single paper makes them. Publications are named by first author and year, and where two papers share a first author and year they are distinguished by journal or by subject.
Contribution character is taken from the publication records. A discovery that rests on work led by another laboratory appears here only with that laboratory named, and the tenOever contribution described. Where the contribution was reagents, supervision or containment-level infection work rather than the discovery itself, the entry says so.
An inefficient splice site paces influenza gene expression, and the same processing step is a vulnerability across the orthomyxovirus family
lab-led
Nucleoprotein availability couples influenza replication competence to immune invisibility, so less replication can yield more interferon
lab-led
Much of the antiviral transcriptome can be induced without interferon, and which genes come on is decided by competition for shared transcription factor subunits
lab-led for Schmid 2010 and Schmid 2014, co-led with the Maniatis laboratory for Ng 2011, and training period for tenOever 2007, which was carried out with the Maniatis and García-Sastre laboratories and is not the independent program's work
Interferon and interferon-stimulated gene loci are held off during homeostasis by a DNA-binding repressor complex that virus entry destroys within minutes
collaborative, led by the Manicassamy laboratory, with Han 2018 published from the University of Chicago with Balaji Manicassamy as corresponding author and Manivasagam 2025 with Priya Issuree and Balaji Manicassamy as corresponding authors. The discovery belongs to those groups. The tenOever contribution is recorded as one author in the Han 2018 list and as investigation in Manivasagam 2025
Engaging the interferon program carries costs that constrain where it can be run, and detection has to be buffered as well as triggered
lab-led for Eggenberger 2019 and for the tenOever 2016 Perspective, which is single-authored and synthesises work largely belonging to other groups. Paget 2023 is collaborative and was led by the Hur laboratory at Harvard with Sun Hur as sole corresponding author, and the tenOever contribution there is recorded as provision of reagents, so that discovery is not this program's
Drosha acts in the cytoplasm during infection and restricts positive-strand RNA viruses by binding structured RNA rather than by producing small interfering RNAs
lab-led
Vertebrate somatic cells do not rely on small RNA silencing against viruses, and the reason is not that such a defence would fail in a mammalian cell
lab-led for Backes 2014, Benitez 2015 on engineered RNA interference, Aguado 2015 and the tenOever 2013 review, co-led with the Cherry laboratory for Backes 2012, and collaborative for Cullen 2013, a Minireview led by Bryan Cullen with Sara Cherry and tenOever
Escape from RNA-guided targeting is set by whether a virus can recombine, and where it cannot, a host editing enzyme can supply the escape
lab-led
Encoding a perturbation in a virus makes tropism, host restriction and viral output experimental variables inside an intact animal
lab-led for Perez 2009, Varble 2010, Langlois 2012 in PNAS, Langlois 2012 in Molecular Therapy, Pham 2012, Varble 2013, Schmid 2014, Benitez 2015 on in vivo screening, Møller 2018 and the tenOever 2019 review, and co-led for Langlois 2013, whose ferret transmission work sits with the Perez and García-Sastre groups. Daniloski 2021 in Cell is co-led with the Sanjana laboratory
Mammalian transmission of influenza founds a new infection from very few genomes, and the restriction lies in the recipient rather than in the virus
lab-led for Varble 2014. McCune 2020 is collaborative and led by the Pfeiffer laboratory at the University of Texas Southwestern, where all mouse work was done, and Muñoz-Moreno 2019 is collaborative and led by the García-Sastre laboratory, with the tenOever contribution in both being the barcoded library method and supervision
The inflammatory character of SARS-CoV-2 infection is something the virus requires rather than something it fails to suppress
lab-led
Interferon generated by airway replication circulates, primes distal organs and is what keeps SARS-CoV-2 respiratory
lab-led
Respiratory infection leaves a persistent inflammatory program in tissues where no virus remains, and olfactory loss is produced in cells the virus never enters
co-led. Frere 2022 and Serafini 2023 are co-corresponding with the Zachariou laboratory, Zazhytska 2022 was led with the Lomvardas and Overdevest groups, and Heaton 2014 is co-led with Peter Palese and tenOever as joint senior and corresponding authors