IKK-Related Kinases and IRF Activation
Which kinases convert pathogen sensing into interferon gene induction?
Research themes
Transcription Factor Selectivity in the Interferon Response
Why do different infections induce different subsets of interferon-stimulated genes?
Homeostatic Repression of Interferon-Stimulated Genes
What holds the antiviral program off when there is no infection?
Interferon and Cell Identity
Is the interferon response compatible with every cell state?
Sensing Aberrant RNA and Restraining the Response
What exactly does the cell detect during infection, and what keeps detection proportionate?
Calibration of the Interferon Response In Vivo
In a whole animal, which cells produce the interferon response, when does it arrive, and what happens when the timing is wrong?
Noncanonical MicroRNA Biogenesis
Can a microRNA be made outside the canonical nuclear pathway?
Does Mammalian Antiviral RNA Interference Exist
Is there evidence that vertebrate somatic cells use small RNA silencing against viruses?
Reconstructing Antiviral RNA Interference
If the system is absent, can it be rebuilt, and what happens when it is?
RNase III Enzymes as Interferon-Independent Antiviral Effectors
Do the enzymes of the silencing pathway have an antiviral role that does not involve silencing?
The Functional Limits of MicroRNAs
What does the microRNA system actually do on the timescale of an infection?
The Evolutionary Logic of Antiviral Defense
Why does each branch of life defend itself the way it does?
MicroRNA-Mediated Viral Attenuation
Can host microRNA expression be used to decide which species or tissue a virus may replicate in?
Cell-Type Restriction as an Experimental Tool
What does a given cell compartment actually contribute to infection and immunity?
Molecular Biocontainment
Can a transmissible virus be made safe to study without changing the biology being studied?
RNA Virus Vectors for Small RNA Delivery
Can an RNA virus deliver a functional small RNA to tissues in an animal?
In Vivo Genetic Screening Through Viral Fitness
Can natural selection inside an infected animal be used as the readout of a genetic screen?
Lineage Tracing of Infected Cells
What happens to a cell that is infected and does not die?
Synthetic Virology as a Method of Inquiry
What is the design vocabulary for rewriting a viral genome?
Small Viral RNAs and the Transcription to Replication Switch
What tells the influenza polymerase to stop transcribing and start replicating?
Splicing and Temporal Control of Segment 8
How does a two-protein segment produce its products in the right order and ratio?
Polymerase, Nucleoprotein and Host Factors
What does the replication machinery require, and what happens when it is short of it?
NS1 and Interferon Antagonism
How much of influenza fitness is set by its interferon antagonist?
The Imbalanced Host Response to SARS-CoV-2
What is distinctive about the transcriptional response to SARS-CoV-2?
Interferon as Intervention and Systemic Priming
If the interferon response is late and weak, does supplying it early help?
Host Factors and Druggable Signaling
Which host proteins does SARS-CoV-2 require, and can any of them be drugged?
Tropism and Permissive Tissues
Which human cell types can SARS-CoV-2 actually infect?
Post-Acute Sequelae of SARS-CoV-2 Infection
What persists after the virus is gone?
Immunity, Age and Reinfection
What does prior exposure or advanced age change about the course of infection?
Models for Pandemic Virology
What experimental system gives an answer that transfers to a human being?
Transmission Bottlenecks and Population Monopolization
How much of a viral population survives a move between hosts or tissues?
Viral Fitness Landscapes
Is adaptation to a host an ordered gradient or a set of divergent routes?
Recombination and Escape from Selective Pressure
What genomic capacity determines whether a virus can escape a given pressure?
Historical Virus Movement
Where and when did a virus lineage travel?