Innate Immune Signaling and the Interferon Response
What determines which genes the interferon system turns on, how strongly, and for how long?
Six questions, one connected program
The research is organized around scientific questions. Each area connects its intellectual history to themes, discoveries, and the publications that support them.
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Small RNA Biology and the Limits of Antiviral Silencing
Do mammals use small RNAs against viruses, and if not, why not?
Programmable Virology
If a virus can be redesigned, what can be learned that cannot be learned any other way?
Influenza Genome Regulation and Replication
How does influenza A virus control the order and amount of its own gene expression?
Pandemic Host Response and Disease
Why does SARS-CoV-2 produce the pattern of disease it does, and what part of that is the host's own response?
Viral Populations, Evolution and Transmission
What survives when a viral population moves between hosts, tissues or species?