Adenovirus

2015 · Cell Host & Microbe · lab-led

microRNA Function Is Limited to Cytokine Control in the Acute Response to Virus Infection

Rapid vector-delivered destruction of the entire cellular microRNA population shows that post-transcriptional silencing makes no measurable contribution to the acute transcriptional response to double-stranded RNA or to type I interferon, while sustained loss of microRNAs derepresses a broad set of chemokines and proinflammatory cytokines in fibroblasts and in mouse lung.

2013 · Nature Reviews Microbiology · lab-led

RNA viruses and the host microRNA machinery

Argues that chordates, unlike plants, nematodes and arthropods, do not use small RNAs as antiviral defence, and that this absence of interplay between host microRNAs and RNA viruses is what leaves the microRNA machinery available for engineering viral tropism and small RNA delivery.