Antigen-specific B cell detection

immunology assays

Recorded terms: antigen-specific B cell staining; biotinylated antigen B cell probe

2022 · Cell Reports · lab-led

A diminished immune response underlies age-related SARS-CoV-2 pathologies

Comparison of young and older golden hamsters infected with SARS-CoV-2 shows that age reduces the magnitude and duration of the innate response and of tissue repair, expands suppressor T cells and IL-17-driven neutrophil recruitment, and lowers germinal centre B cell frequency and neutralizing antibody potency without raising lung virus titres.

2021 · Science Immunology · lab-led

Immune memory from SARS-CoV-2 infection in hamsters provides variant-independent protection but still allows virus transmission

Longitudinal tracking of antigen-specific lymphocytes in golden hamsters shows that memory from the founder strain of SARS-CoV-2 clears a beta variant rechallenge and that transferred memory T cells alone lower viral load, yet protected animals still infected every cohoused naive partner.