TechnologiesBehavioural and sensory testing
animal, organoid and tissue models
Recorded terms: buried food finding test; Hargreaves thermal testing; locomotor beam break assay; marble burying assay; von Frey monofilament testing
2023 · Science Signaling · co-led
Intranasal SARS-CoV-2 infection of golden hamsters deposits viral RNA without infectious virus in dorsal root ganglia and spinal cord, producing a milder but longer-lasting mechanical hypersensitivity than influenza A virus and a neuropathic dorsal root ganglion transcriptome at 31 days, from which ILF3 emerges as an analgesic target validated in mouse pain models.
2022 · Science Translational Medicine · co-led
Benchmarked against pandemic influenza in golden hamsters, SARS-CoV-2 uniquely sustains interferon signaling, chemokine production and myeloid activation in olfactory bulb and epithelium a month after clearance, alongside altered behavior and matching signatures in recovered human olfactory tissue.