TechnologiesComparative genomics and conservation analysis
sequence and population analysis
Recorded terms: comparative genomics; comparative sequence conservation analysis; evolutionary parsimony analysis
2022 · Science Signaling · collaborative
Kinase substrate specificity profiling assigns the phosphorylation cluster in the SARS-CoV-2 nucleocapsid SR-rich domain to a cascade initiated by SRPK1 and SRPK2 and extended by GSK-3 and casein kinase 1, whose inhibition suppresses coronavirus replication.
2016 · Cell Host & Microbe · lab-led
A synthesis arguing that antiviral defenses across the three domains of life reuse a small set of designs, antisense recognition joined to nuclease activity and later to transcriptional and secreted responses, and proposing that chordates lost RNA interference through incompatibility with interferon.