Cell type deconvolution of bulk transcriptomes

transcriptomics and epigenomics

Recorded terms: cell type deconvolution; RNA sequencing deconvolution

2023 · Science Signaling · co-led

SARS-CoV-2 airway infection results in the development of somatosensory abnormalities in a hamster model

Intranasal SARS-CoV-2 infection of golden hamsters deposits viral RNA without infectious virus in dorsal root ganglia and spinal cord, producing a milder but longer-lasting mechanical hypersensitivity than influenza A virus and a neuropathic dorsal root ganglion transcriptome at 31 days, from which ILF3 emerges as an analgesic target validated in mouse pain models.

2022 · Science Translational Medicine · co-led

SARS-CoV-2 infection in hamsters and humans results in lasting and unique systemic perturbations after recovery

Benchmarked against pandemic influenza in golden hamsters, SARS-CoV-2 uniquely sustains interferon signaling, chemokine production and myeloid activation in olfactory bulb and epithelium a month after clearance, alongside altered behavior and matching signatures in recovered human olfactory tissue.