TechnologiesDirected differentiation of human pluripotent stem cells
animal, organoid and tissue models
Recorded terms: directed differentiation of human pluripotent stem cells; directed trilineage differentiation; embryoid body cardiomyocyte differentiation; hPSC ScoreCard assay
2020 · Cell Stem Cell · collaborative
A panel of eight human pluripotent stem cell derivatives spanning all three germ layers, together with adult primary islets and liver organoids, identifies pancreatic alpha and beta cells, hepatocytes, cholangiocytes, cardiomyocytes and dopaminergic neurons as permissive to SARS-CoV-2 and shows that permissiveness does not track ACE2 expression alone.
2019 · Proceedings of the National Academy of Sciences · lab-led
Forcing an interferon-stimulated gene program in human induced pluripotent stem cells with a constitutively active IRF7 produces lasting transcriptional change and impaired germ layer differentiation, supporting the proposal that the canonical type I interferon system and pluripotency are difficult to hold simultaneously.