TechnologiesDoxycycline-inducible lentiviral expression
functional genomics and screening
Recorded terms: doxycycline-inducible lentiviral expression; lentiviral doxycycline-inducible expression
2023 · Journal of Virology · lab-led
Archaeal members of the L30 protein family, but not their orthologues from any other domain of life, block production of the spliced influenza A virus, influenza B virus and isavirus transcripts without measurably disturbing host splicing, identifying a shared and apparently noncanonical feature of orthomyxovirus splicing.
2019 · Proceedings of the National Academy of Sciences · lab-led
Forcing an interferon-stimulated gene program in human induced pluripotent stem cells with a constitutively active IRF7 produces lasting transcriptional change and impaired germ layer differentiation, supporting the proposal that the canonical type I interferon system and pluripotency are difficult to hold simultaneously.