TechnologiesPromoter motif discovery and enrichment
transcriptomics and epigenomics
Recorded terms: motif discovery; motif enrichment analysis
2025 · Cell Host & Microbe · collaborative
The Capicua and ATXN1L repressor complex binds an eight-nucleotide motif at interferon and interferon-stimulated gene loci to hold them repressed during homeostasis in human and mouse cells, and is degraded through EGFR-MAPK signaling early in respiratory viral entry, which relieves that repression.
2011 · Proceedings of the National Academy of Sciences · co-led
Phosphorylation of STAT1 serine 708 by IKKε blocks formation of the STAT1 homodimer that constitutes GAF while leaving the STAT1 and STAT2 heterodimer of ISGF3 intact, biasing the shared STAT1 pool and the interferon-stimulated transcriptome toward the type I response.