tenOever LaboratoryVirology · Host defense · RNA biology
Technologies

Chimeric minigene splicing reporters

proteomics and biochemistry

Recorded terms: chimeric minigene reporters

2023 · Journal of Virology · lab-led

Archaeal Kink-Turn Binding Protein Mediates Inhibition of Orthomyxovirus Splicing Biology

Archaeal members of the L30 protein family, but not their orthologues from any other domain of life, block production of the spliced influenza A virus, influenza B virus and isavirus transcripts without measurably disturbing host splicing, identifying a shared and apparently noncanonical feature of orthomyxovirus splicing.